Polysubstance Use: Mixing Stimulants


Stimulants (aka “uppers”) can increase your heart rate and blood pressure to dangerous levels and increase your risk of several serious health problems.

Examples: ecstasy (MDMA), cocaine, methamphetamines, amphetamines (speed)

Mixing Stimulants

Combining stimulants may even directly or indirectly increase your rise of brain injury, liver damage, heart attack, stroke. It also increases the risk of psychosis, anxiety, or panic attacks. The likelihood of experiencing serotonin syndrome, a harmful drug reaction caused by too much serotonin, is also increased. Side effects of serotonin syndrome can include mental confusion, hyperactivity, muscular problems, fever and sweating, rapid heartbeat, muscle spasms, and death.

More Information

Polysubstance Use Facts | Stop Overdose | CDC

Polydrug use – Alcohol and Drug Foundation (adf.org.au)